منابع مشابه
[Eaton-Lambert syndrome].
In the myasthenic syndrome sometimes associated with bronchogenic carcinoma (Eaton-Lambert syndrome) muscular weakness is caused by reduced acetylcholine release from motor nerve terminals (Elmqvist and Lambert, 1968). Guanidine is a potent drug in this condition (Lambert, 1966) but serious adverse reactions have been reported (Lambert and Howard, 1972; Cherington, 1976; Henriksson et al., 1977...
متن کاملLambert-Eaton myasthenic syndrome.
Lambert-Eaton myasthenic syndrome (LEMS) is an idiopathic or paraneoplastic syndrome producing antibodies against presynaptic voltage-gated P/Q calcium channels. This decreases calcium entry into the presynaptic terminal, which prevents binding of vesicles to the presynaptic membrane and acetylcholine release. LEMS is most often associated with small cell lung cancer, although idiopathic presen...
متن کاملTransient Lambert-Eaton myasthenic syndrome associated with systemic lupus erythematosus.
We present a patient who developed the Lambert-Eaton myasthenic syndrome (LEMS) in association with systemic lupus erythematosus (SLE). Severe proximal weakness with electrodiagnostic evidence of LEMS developed over 2 days during an exacerbation of cutaneous manifestations (bullous pemphigoid) associated with SLE. Following an increase in the daily dose of prednisone, there was complete clinica...
متن کاملClassic diseases revisited Lambert-Eaton myasthenic syndrome
The Lambert-Eaton myasthenic syndrome is a neuromuscular disorder characterised by defective neurotransmitter release at autonomic neurones and presynaptic terminals of the neuromuscular junction. It is caused by an IgG autoantibody formed against especially the P/Q type of voltagegated calcium channels (VGCC) which is an essential component of the mechanism of neurotransmitter release. Many pa...
متن کاملEaton-Lambert Syndrome Associated with Pituitary Apoplexy
A case of Eaton-Lambert syndrome associated with pituitary apoplexy is presented. It is thought to be the first reported case. The clinical features, electrophysiological findings and effects and side effects of therapeutic drugs are noted. Endocrinological dysfunctions are discussed in relation to pituitary disorder.
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 2006
ISSN: 0022-3050
DOI: 10.1136/jnnp.2006.091504